How does low weight molecular hydrolyzed collagen get to the dermis?

Comment le collagène hydrolysé faible poids de masse va-t-il vers le derme ?

What is used in our formulas?





Marine hydrolyzed collagen with a low molecular weight contains oligopeptide fractions with a great ability to interact with the skin and hair.






  • Low molecular weight collagen fractions with a high level of oligopeptides (mainly 0.3 to 2 KDa)




  • Oligopeptides (Glycine, Proline and Hydroxyproline) with high concentrations of essential amino acids





What are the scientific claims in regards of percutaneous penetration?






  1. Help increase Collagen I in human skin (ex vivo)




  2. Contribute to increase Collagen III in human skin (ex vivo)




  3. Help boost hyaluronic acid in human skin. (ex vivo)





Studies that support our claims:






  • Low Molecular weight Collagen : Hydrolyzed Collagen has a low molecular weight that allows them to travel down to the dermis.









Very low molecular weight collagen fractions (<1000Daltons) typically represent 40% of the total composition, and low molecular weight fractions (1000-2000 Daltons) represent 30% of the selected Marine Hydrolyzed Collagen.










  • Collagen I Expression :

    • Culture: ex vivo human skin , female, 62 years old




    • Application: Marine Hydrolyzed Collagen twice a day for 72 hours




    • Evaluation: immunodetection of collagen I







Results: Skin treated with Marine Hydrolyzed Collagen shows a more intense green staining intensity, suggesting an increased quantity of collagen I in the dermis of ex VIVO human skin.










  • Collagen III Expression :

    • Culture: ex vivo human skin , female, 62 years old




    • Application: Marine Hydrolyzed Collagen twice a day for 72 hours




    • Evaluation: immunodetection of collagen III







Results: Skin treated with Marine Hydrolyzed Collagen shows a more intense green staining intensity, suggesting an increased quantity of collagen I in the dermis of ex VIVO human skin.










  • Hyaluronic Acid Expression:

    • Culture: ex vivo human skin , female, 62 years old




    • Application: Marine Hydrolyzed Collagen twice a day for 72 hours




    • Evaluation: Fluorescent staining







Results: Marine Hydrolyzed Collagen may help increase the quantity of hyaluronic acid in ex vivo human skin.






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